Haoze Supply Clomipramine CAS 303-49-1 Clomipramine Powder

• Powder: Yes
• Customized: Non-Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Adult
• State: Powder
• Purity: >99%
• Model NO.: HZ-Clomipramine
• Grade: Pharmaceutical Grade
• Appearance: White Powder
• Odor: Characteristics
• Assay: 99%
• CAS: 303-49-1
• Einecs: 206-144-2
• Formula: C19h23cln2
• Transport Package: 25kg/CTN
• Specification: 25kg/ctn
• Origin: China
• HS Code: 2933990099
• Production Capacity: 10000kg/Month

Product Description

Product Description

Clomipramine is a safe and reliable tricyclic antidepressant with rapid action. It is white or yellowish crystalline powder at room temperature. Odorless, bitter taste; The light color changes to yellow. It is highly soluble in glacial acetic acid, easily soluble in water or ethanol, and almost insoluble in ether.

Synonym
g34586;Hydiphen;Monochlorimipramine;RARECHEM AX KI 5027;CLOMIPRAMINE HYDROCLORIDE;AURORA KA-7606;CHLORIMIPRAMINE;CHLORIMIPRAMINE HYDROCHLORIDE

Product Name:	Clomipramine	CAS NO.:	303-49-1
Molecular weight:	314.85	EINECS:	206-144-2
Formula:	C19H23ClN2	Density:	1.0568 (rough estimate)

Detailed Photos

                                                                 

Function & Application

Function
Clomipramine produces antidepressant effects by inhibiting the reuptake of norepinephrine (NA) and 5-hydroxytryptamine (5-HT) in the presynaptic membrane, as well as anxiolytic and sedative effects. The inhibitory effect of 5-hydroxytryptamine reuptake is stronger than that of other tricyclic drugs, while the inhibitory effect of norepinephrine reuptake is less than that of imipramine and amitriptyline. Its anticholinergic effect is moderate and its sedative effect is low. It is well absorbed after oral administration. The therapeutic blood concentration is 200-500ng/ml, and the steady-state blood concentration can be reached in 1-2 weeks. After hepatic metabolism, the concentration of the active metabolite norclomipramine is twice the concentration of the original drug. The plasma protein binding rate is 96Chemicalbook~97%, and the half-life is 21~31 hours. About 70% is excreted in urine and 30% is excreted in feces. It is suitable for the treatment of endogenous, reactive, neurological, latent depression and various depressive states; schizophrenia accompanied by depression; obsessive-compulsive disorder, phobia; various pain, etc. The drug can also reduce the levels of 5-hydroxyindoleacetic acid (5HIAA) in cerebrospinal fluid and platelets, which is related to the drug's ability to treat obsessive-compulsive disorder. It has affinity for D2 receptors, alpha-adrenergic receptors, and histamine receptors. In addition, it has strong anticholinergic effects and mild dopamine antagonism that can increase plasma levels of prolactin.

Drug interactions

1. Concomitant use with ethanol can cause central nervous system depression.
2. Concomitant use with anticonvulsants can lower the epilepsy threshold, thereby reducing the effect of anticonvulsants, and the dosage of antiepileptic drugs must be adjusted.
3. When used together with antihistamines or anticholinergics, the drug effects will strengthen each other, and the dosage needs to be adjusted in time.
4. When guanethidine and clomipramine are used together, the antihypertensive effect of the former may be reduced. However, when the dosage does not exceed 150mg per day, the efficacy of guanethidine will not be affected by Chemicalbook.
5. When used together with estrogen or estrogen-containing contraceptives, it can increase the adverse reactions of clomipramine and reduce the antidepressant efficacy.
6. Combined use with monoamine oxidase inhibitors can cause hypertensive crisis, and death has been reported. Generally, the former should be stopped for two weeks before use.
7. Combined use with adrenergic receptor agonists may cause severe hypertension and high fever.
8. Combined use with thyroid preparations can synergize with each other and cause arrhythmia, so the dosage of both must be reduced.

Application
Clomipramine can treat various depressive states; treat obsessive-compulsive neurosis and phobic neurosis.

We could also do the OEM and ODM for customer

Our Advantages

Our Advantages:

---We are very experienced with this field(more than 10 years);
---Good after-sales service
---100% quality guaranteed;
---We accept sample order for testing;
---Strong supply ability;
---Provide various customizations,
---Made in China gold members with high credit guarantee.

Certifications

Xi'an Haoze Biotechnology Co., Ltd. established in 2015, is a professional engaged in the research, development, sale, and service of Turkesterone, NMN, Astaxanthin, Curcumin, Coenzyme Q10.We are located in Xi'an with convenient transportation access. we have excellent teams who focus on product development & design, quality control & inspection, and company running. Dedicated to strict quality control and thoughtful customer service, our experienced staff members are always available to discuss your requirements and ensure full customer satisfaction. In addition, we have obtained ISO9001,HALAL and Kosher certificates. Selling well in all cities and provinces around China, our products are also exported to clients in such countries and regions as North America, Europe, Oceania, and the Middle East. If you have any new ideas or concepts for the products, please contact us. We are glad to work together with you and finally bring you the satisfied products.We also welcome OEM and ODM orders. Whether selecting a current product from our catalog or seeking engineering assistance for your application, you can talk to our customer service center about your sourcing requirements."Top Quality, Customer First" is our adhering, to and implementing the principle of "high standards, safe & fast delivery, good service", to create a mutual benefit partnership with customers. We warmly welcome customers from at home and abroad to establish cooperation and create a bright future with us together.

FAQ

Q1: Could i start the order with small quantity ? 

A: We accept sample order , the more details please contact us to know about. 

Q2: Could you accept customzied order? 
A: Yes, we accept customized service according your inquire, you can communicate with sales manager to know more details.

Q3: When the product can be delivery? 
A: We normal delivery the product within 2-4 days, the more details will inform to you by our sales manager. 

Q4: Could i get certificate of analysis (COA) about product?
A: Of course, please contact us to get it.