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Cepharanthine is a bisegmylisovailine alkaloid isolated from Cephaleuca capitana and Diphaleuca diphaleuca. It has the effects of anti-tumor, anti-malaria, bacteriostasis and immune regulation. Modern studies suggest that it also has the function of stimulating reticuloendothelial system, activating hematopoietic tissue and promoting the proliferation of bone marrow tissue. It has been clinically used in the prevention and treatment of leukopenia caused by radiotherapy, chemotherapy and other reasons in cancer patients, and has received certain effects. Therefore, Cephaletin is considered to be a low-toxicity and effective leukocytotropic drug. Cephalotin can partially reverse the multidrug resistance of leukemia cells, and the effect is obviously better than the classical reversal drug verapamil, and the cytotoxic effect is much less than verapamil at reverse dose. Foreign studies have also shown that Cephaletin has a good reverse effect on a variety of drug resistant cells. Cephaletin can enhance the immune function of macrophages and cells in vivo. In Japan, Cephaletin has been used as a leukocytogenic drug for more than a year in clinical practice, with no obvious toxic side effects. It has been used for experimental treatment of pneumoconiosis for many years. These results suggest that cephaletin has great clinical value.
Product Name: | Cepharanthine | Assay: | 99% |
Appearance: | White powder | Formula: | C37H38N2O6 |
CAS: | 481-49-2 | EINECS | 228-085-1 |
Storage: | Keep in cool & dry place, stay away from strong light and heat | Application: | Antineoplastic |
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Function
Cepharanthine has potential antitumor effect. Cephaletin alone can play an antitumor role by inhibiting the proliferation of tumor cells and enhancing the body's immunity. What is more promising is that Cephaletin combined with chemotherapy drugs can improve the efficacy of chemotherapy by reducing the resistance of cells. The main mechanism may be that Cephaletin increases the accumulation of anticancer drugs in cells by interfering with the function of plasma membrane. In addition, Cephaletin can also improve the sensitivity of tumor cells to radiotherapy. The direct antitumor effect of Cephaletin: Cephaletin can enhance the body's anti-tumor ability by enhancing the body's immune response. Macrophages can specifically recognize and kill tumor cells and play a crucial role in anti-tumor immunity. However, in tumor-developing individuals, macrophages are often inhibited. It may be related to its role in the treatment of tumors. In addition, it is an important mechanism for tumor inhibition to be activated by T cells or by direct action on macrophages. Cephaletin plays an antitumor role by acting on macrophages, T cells and NK cells to enhance the anti-tumor immunity of the body. Cephalotin may be a multi-target and multi-effect drug, its anti-tumor pharmacological action is complex, and its molecular mechanism remains to be further explored. The antitumor effect of Cephaletin was confirmed by the experimental results in various tumor cells.
Application
1. Cepharanthine can is used for promoting bone marrow tissue hyperplasia
2. Cepharanthine can is used for treating leukocytes decrease and lack caused by cancer chemotherapy and other factors
3. Cepharanthine can is used for treating thrombocytopenic purpura
4. Cepharanthine can is used for inhibiting pulmonary fibrosis without significant adverse reactions
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