Introduction:
Benfotiamine is an organic compound with the molecular formula C19H23N4O6PS, molecular weight 466.45, chemical name: benzoic acid-sulfur-2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]methyl Amide]-1-[2-(phosphoryloxyethyl)-1-propenyl] ester appears as a white crystalline powder.
Details:
Product Name:Benfotiamine
CAS:22457-89-2
MF:C19H23N4O6PS
MW:466.45
EINECS:245-013-4
Mol File:22457-89-2.mol
Melting point:165 C
Boiling point:745.1±70.0 °C(Predicted)
Density 1.444±0.06 g/cm3(Predicted)
storage temp. 2-8°C
COA:
ITEM |
SPECIFICATION |
RESULT |
METHOD |
Appearance |
White powder, neutral odor, highly hygroscopic |
Conforms |
Visual |
Identification |
Standard solution and test solution same spot,RF |
Conforms |
TLC |
Specific Optical |
-2.4°~ -2.8° |
-2.72° |
|
Heavy metals (as PB) |
≤10ppm |
Conforms |
AAS |
Sulfate (SO4) |
≤0.02% |
Conforms |
Colorimetry |
Chloride (Cl) |
≤0.02% |
Conforms |
Colorimetry |
Phosphate Ion (P) |
≤5ppm |
Conforms |
Colorimetry |
Residual solvent(ethanol) |
≤1.0% |
Conforms |
HS-GC |
pH |
4.5~7.0 |
5.10 |
|
Related substance |
Spot not bigger than standard solution spot |
No spot |
TLC |
Water Content |
≤2% |
0.26% |
KF |
Assay (dried basis) |
98.0%--102.0% |
99.48% |
Potentiometric titration |
Assay (dried basis) |
98.5%--100% |
99.2% |
HPLC |
Application:
Benfotiamine is useful for the treatment of diabetic retinopathy, neuropathy, and nephropathy however "Most of the effects attributed to benfotiamine are extrapolated from in vitro and animal studies. Unfortunately apparent evidences from human studies are scarce and especially endpoint studies are missing. Therefore additional clinical studies are mandatory to explore the therapeutic potential of benfotiamine in both diabetic and non-diabetic pathological conditions".
Function:
1. Benfotiamine is used for the prevention and treatment of vitamin B1 deficiency;
2. For vitamin B1 demand increase, with inadequate intake from foods supplies (fatigue, hyperthyroidism, pregnancy, lactation, during strenuous manual labor, etc.);
3. Benfotiamine is used in the treatment of non alcoholic wernicke encephalopathy;
4. To treat beriberi;
5. Used in the following diseases, speculation and vitamin B1 deficiency and metabolic disorders associated with treatment, such as: neuralgia; Muscle pain, joint pain; Peripheral neuritis, peripheral nerve palsy; Myocardial metabolic disorders; Constipation and other gastrointestinal motor function obstacle.
Goods weight
|
Packing
|
Shipping method
|
Lead-time
|
1-50kg
|
Below 5kg Use Foil bag;5-25kg use two layer PP bag,then into master carton or cardboard drum
|
International express
|
1~3 days after your payment |
100-200kg
|
25kg/drum,use two layer PP bag,then into cardboard drum
|
Air shipping
Sea Shipping |
3~5 days after your payment |
Over 500kg
|
25kg/drum,use two layer PP bag,then into cardboard drum
|
Sea shipping
|
5~10 days after your payment |
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Q1: Can I get some free sample?
A: Yes, we offer free sample to client and you only need to pay the fright.
Q2: Could you accept customzied order?
A: Yes, we accept customized service according your requests, you can communicate with sales manager to know more details.
Q3: When the product can be delivery?
A: We normal delivery the product within 2-4 days, the more details will inform to you by our sales manager.
Q4: Could i get certificate of analysis (COA) about product?
A: Of course, please contact us to get it.
Q5: Is there any discount?
A:Yes, we can give you discount, but it depends on your quantity.