| Customization: | Available |
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| CAS No.: | 68-19-9 |
| Formula: | C63h88con14o14p |
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Vitamin B12, referred to as VB12, also known as cobalamin, one of the B vitamins, is a class of cobalt-containing complex organic compounds, the trivalent cobalt contained in the porphyrin-like gollinoid ring plane center. It is the largest and most complex vitamin molecule found and the only one containing metal ions. Its crystallization is red, so it is also called red vitamin. Plants do not contain VB12 and cannot make it. Liver is the best source of VB12, followed by milk, meat, eggs, fish and so on. Deficiency of VB12 in vivo can cause pathological changes in the nervous system such as peripheral nerve and central encephalopathy. A prototype of a family of natural cobalt coordination compounds called corrinoids. Vitamin B12 analogues differ only in the beta ligand of cobalt, called cobalamin. Almost entirely synthesized by bacteria. Dietary sources include fish, meat, liver and dairy products; There is little or no cobalamin in plants. Methylcobalamin and cobalamin act as co-factors of enzymes and are converted by the body into their biologically active forms. Severe deficiency can lead to megaloblastic anemia and/or nerve damage. The discovery of vitamin B12 was first attributed to the work carried out in the treatment of a malignant anemia named after the English physician Addison. It was an incurable disease at the time, and in 1926 Minot and Murphy discovered that it could be cured by ingesting large quantities of raw liver, for which they were awarded the 1934 Nobel Prize in Physiology and Medicine. Following the discovery of Minot and Murphy, this malignant anaemia was successfully treated with liver concentrate. In 1948, Riches in the United States and Smith and Parker in the United Kingdom separated a red crystal from liver concentrate and named it vitamin B12. In the same year, R.W. of Columbia University in the United States proved that malignant anaemia can be effectively treated by injecting vitamin B12. Then in 1955, D. Hedgkin et al. determined the crystal structure of vitamin B12 by X-ray analysis. He won the 1964 Nobel Prize in Chemistry for his work. In 1972, Woodward successfully completed the complete synthesis of vitamin B12.
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| Product Name: | Vitamin B12-Cyanocobalamin | Assay: | 1% |
| Appearance: | Red to dark red powder | CAS NO: | 68-19-9 |
| Formula: | C63H88CoN14O14P | Molecular weight: | 1355.37 |
| EINECS: | 200-680-0 | Application: | food additive as the nutrition enhancer |
1. Improve the utilization rate of folate synthesize methionine (synthesized by homocysteine) and choline together with folate, synthesize cyanocobalamin schenyl precursor substances such as methylcobalamin and coenzyme B12 in the process of producing purine and pyrimidine, and participate in the methylation process of many important compounds. When vitamin B12 is deficient, the activity of transferring methyl groups from methyltetrahydrofolate is reduced, making folate into an unusable form, resulting in folate deficiency.
2. Maintain the metabolism and function of nerve myelin. When vitamin B12 is deficient, it can cause neurological disorders, degeneration of the spinal cord, and can cause severe psychiatric symptoms. Vitamin B12 deficiency can lead to peripheral neuritis. The early manifestation of vitamin B12 deficiency in children is abnormal mood, dull expression, slow reaction, and finally anemia.
3. Promote the development and maturation of red blood cells. The conversion of methylmalonyl-CoA to succinyl-CoA participates in the tricarboxylic acid cycle, in which succinyl-CoA is involved in the synthesis of heme.
4. Vitamin B12 also participates in the synthesis of deoxynucleic acid (DNA), metabolism of fats, carbohydrates and proteins, and increases the synthesis of nucleic acids and proteins.
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1. All of our ingredients meet strict quality and food safety standards, and surpass industry standards for purity and cleanliness.
2. Our food ingredients are certified to applicable organic standards: National Organic Program (NOP) and European Union (EU).
3. We use organic certificate who meet or exceed IFOAM standards and are accepted worldwide.
4. We also can provide ISO, HACCP, KOSHER certification.
| Cargo weight | Packing | Shipping method | Lead-time |
| 5-50kg | Below 5kg Use Foil bag;5-25kg use two layer PP bag,then into master carton or cardboard drum | International express | 7-10days |
| 100-200kg | 25kg/drum,use two layer PP bag,then into cardboard drum | Air shipping | 7-10days |
| Over 500kg | 25kg/drum,use two layer PP bag,then into cardboard drum | Sea shipping | 20-55days |
Xi'an Haoze Biotechnology Co., Ltd. established in 2015, is a professional engaged in the research, development, sale, and service of Turkesterone, NMN, Astaxanthin, Curcumin, Coenzyme Q10.We are located in Xi'an with convenient transportation access. we have excellent teams who focus on product development & design, quality control & inspection, and company running. Dedicated to strict quality control and thoughtful customer service, our experienced staff members are always available to discuss your requirements and ensure full customer satisfaction. In addition, we have obtained ISO9001,HALAL and Kosher certificates. Selling well in all cities and provinces around China, our products are also exported to clients in such countries and regions as North America, Europe, Oceania, and the Middle East. If you have any new ideas or concepts for the products, please contact us. We are glad to work together with you and finally bring you the satisfied products.We also welcome OEM and ODM orders. Whether selecting a current product from our catalog or seeking engineering assistance for your application, you can talk to our customer service center about your sourcing requirements."Top Quality, Customer First" is our adhering, to and implementing the principle of "high standards, safe & fast delivery, good service", to create a mutual benefit partnership with customers. We warmly welcome customers from at home and abroad to establish cooperation and create a bright future with us together.
Q: How to start orders or make payments?
You can send our your Purchase order(if your company has), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly. It is also ok for western union ,money gram, Paypal and others.
Q: How to confirm the Product Quality before placing orders?
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the
samples.
Q: What's your MOQ?
For the high value product, our MOQ starts from 1g and generally starts from 10gs.
For other low price product, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
Yes, for larger quantity, we always give the best price.
Q:How do you treat quality complaint?
First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we
will send you free goods for replacement or refund your loss.
Q:How to contact us ?
You can choose your interested products and send inquiry to us.
You can dial our telephone or whatsapp: directly, you will get our reply.
Send Email to us.
Q:what is the shipping way ?
For small order ,we ship by air express ,like Fedex, TNT,DHL,EMS ,
For large order ,we can send by air to the air port and send by sea to the sea port
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