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Carnitine is one of the B vitamins with a structure similar to amino acids, so it has been classified as amino acids. Its main role is to help transport long chain fatty acids to provide energy. This prevents fat accumulation in the heart, liver, and skeletal muscle. There are three forms of artificially synthesized carnitine: left-handed, dextral, and racemic. The effect of L-carnitine is better. L-carnitine is a compound with multiple physiological active functions, whose main function is to promote fatty acids β- Oxidation; It can also regulate the ratio of acyl groups in mitochondria and affect energy metabolism; L-carnitine can participate in the transportation of branched chain amino acid metabolites, thereby promoting the normal metabolism of branched chain amino acids. In addition, L-carnitine plays a role in the elimination and utilization of ketone bodies, and can be used as a biological antioxidant to remove free radicals, maintain membrane stability, improve animal immunity, and resist disease and stress. Recent studies have shown that L-carnitine and acetyl L-carnitine play an important carrier role in energy metabolism in sperm mitochondria, clearing ROS and protecting sperm membrane function. Oral administration of L-carnitine and acetyl L-carnitine can increase the total number of forward motility sperm and motility sperm in patients with oligozoospermia and asthenospermia, and increase the clinical pregnancy rate of women, which is safe and effective. Clinical experimental studies at home and abroad have shown that carnitine in the treatment of male infertility is a new breakthrough in the field of drug therapy for male infertility in recent years, and in-depth research is necessary to further clarify its mechanism of action and clarify its indications.
Nootropic | |||
Sunifiram | 314728-85-3 | Coluracetam | 135463-81-9 |
Fasoracetam | 110958-19-5 | Noopept | 157115-85-0 |
PRL-8-53 | 51352-87-5 | Beta nicotinamide mononucleotide | 1094-61-7 |
Nicotinamide ribose | 1341-23-7 | Aniracetam | 72432-10-1 |
Oxiracetam | 62613-82-5 | Pramiracetam | 68497-62-1 |
Nebracetam | 116041-13-5 | Nefiracetam | 77191-36-7 |
Phenylpiracetam | 77472-70-9 | Piracetam hydrazide | 59776-89-5 |
NSI-189 | 1270138-40-3 | NSI-189 phosphate | 1270138-41-4 |
Alpha-GPC | 28319-77-9 | Citicoline | 987-78-0 |
Citicoline Sodium | 33818-15-4 | 4-Aminobutyric acid | 56-12-2 |
Phenibut | 1078-21-3 | Sulbutiamine | 3286-46-2 |
Unifiram | 272786-64-8 | Amfonelic acid | 15180-02-6 |
Function:
Recent studies have shown that L-carnitine also has certain promoting effects on ketone body utilization and nitrogen metabolism.
• Promote the transportation and oxidation of fatty acids
Fatty acid β- Oxidation occurs in the mitochondria of the liver and other tissue cells. It is known that neither free fatty acids nor acyl coenzyme A can penetrate the inner membrane of mitochondria, while acyl carnitine can rapidly pass through this membrane, confirming that L-carnitine is a carrier for transporting fatty acids in the form of acyl groups from outside the mitochondrial membrane to inside the membrane. The detailed mechanism of this transport is unclear, but it is certain that carnitine acyl co A transferase is the key enzyme in this process. Some people believe that L-carnitine can also participate in the transport and excretion of other acyl groups, thereby preventing metabolic poisoning caused by the accumulation of acyl groups in the body or facilitating the normal metabolism of some branched chain amino acids.
• Accelerate sperm maturation and improve vitality
L-carnitine is an energy substance for sperm maturation, which has the function of increasing sperm number and vitality. A survey of 30 adult males showed that the number and vitality of sperm were within a certain range proportional to the dietary supply of L-carnitine, and the content of L-carnitine in sperm was also positively correlated with the dietary content of L-carnitine.
• Improve the tolerance of the body
Research by Watanabe et al. has found that L-carnitine can improve the tolerance of patients with diseases during exercise, such as exercise time, maximum oxygen absorption, lactate threshold, oxygen absorption threshold, and other indicators. After supplementation with L-carnitine, the body will have varying degrees of improvement; Oral L-carnitine can also increase muscle tolerance at maximum oxygen absorption by 80%, shorten the recovery period after vigorous exercise, and reduce the tension and fatigue caused by exercise. In 1986, Santulli et al. found that L-carnitine can increase the growth rate of hatched cultured bass and reduce the content of cholesterol and triglycerides in fish tissue. Germany reported that athletes' body fat content significantly decreased after 3 weeks of L-carnitine intake, and the proportion of protein increased, but their weight was not affected.
Application:
L-carnitine, as a new nutritional fortifier, has been widely used in functional foods, especially as an additive in infant formula foods, athlete foods, and weight loss . The main commercial L-carnitine salts are their hydrochloride, tartrate, and magnesium citrate salts.
(1)Application of L-carnitine in infant formula plays an important role in the metabolic process of infants using fat as a source of energy.
Due to the weak biosynthetic ability of L-carnitine in infants, it is necessary to ingest exogenous L-carnitine to ensure that the body's fat is in the optimal oxidation state and provide sufficient energy to maintain normal infant temperature. In addition, L-carnitine can also promote the growth and development of infants and improve metabolic balance. Therefore, it is necessary to strengthen L-carnitine in infant and young children's foods, especially soy based infant formula foods, because the content of L-carnitine in soy is very low. The limit for L-carnitine in infant formula foods in China is 70-90 mg/kg. Currently, L-carnitine fortified infant formula milk powder has been marketed in China.
(2)Application in athlete foods
According to reports by Decombaz J. et al., the concentration of free carnitine in human muscle tissue will decrease by 20% after vigorous exercise. It is believed that supplementing carnitine can improve the body's sense of fatigue, because L-carnitine can promote fat oxidation in the body, provide sufficient energy for the body, and contribute to the improvement of exercise endurance and explosive power. When used in combination with L-carnitine, it has a multiplier effect on physical strength, manifested in relaxation of the muscles throughout the body, improvement in explosive power and endurance, increase in basal metabolic rate, and improvement in the nutritional status of the myocardial layer. The commonly used method is to add L-carnitine to athletes' drinks for fortification.
(3)Application in weight loss
As early as the 1970s, there were patent reports on the use of DL carnitine in the prevention and treatment of obesity. Subsequently, DL carnitine was replaced by L-carnitine due to the discovery of negative effects. Practice has proven that L-carnitine fortified foods have a good effect on fat metabolism disorders caused by carnitine deficiency in the body, and can prevent obesity, fatty liver, and other diseases caused by the accumulation of lipids in muscle fibers and liver. Sang Tianyou believes that obese individuals with insufficient exercise accumulate more fat and have a low biosynthetic capacity for carnitine. By ingesting L-carnitine, they can effectively convert excess fat into energy and release it, which plays a role in preventing and treating obesity. Therefore, L-carnitine as the main ingredient of lipid lowering foods is popular in the European market
We accept International Express--Fedex/DHL/UPS, air shipping and sea shipping
Cargo weight |
Packing |
Shipping method |
Lead-time |
5-50kg |
Below 5kg Use Foil bag;5-25kg use two layer PP bag,then into master carton or cardboard drum |
International express |
1~3 days after your payment |
100-200kg |
25kg/drum,use two layer PP bag,then into cardboard drum |
Air shipping |
3~5 days after your payment |
Over 500kg |
25kg/drum,use two layer PP bag,then into cardboard drum |
Sea shipping |
5~9 days after your payment |
1. Can I get some free sample of you product?
Yes, we offer free sample to client but the shipping cost will be paid by client.
2. How to make payment and what is the payment term?
Payment can be done by T/T, Credit Card, Western Union, PayPal and more.
3. How does your factory make sure the product quality?
First of all, we have about 10years experience in raw materials, we already have a mature quality control procedure. Also we will final check before shipping to avoid any problem.
4.Can you do OEM for me?
We accept OEM orders, just contact us and send us your request. We will offer you a reasonable price and make samples ASAP. [email protected]