High Purity 99% Cancer Treatment Afatinib API Bibw2992 CAS 439081-18-2

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Model NO.: HZ-Afatinib
• Grade: Healethcare Products
• CAS No.: 439081-18-2
• Appearance: White Crystal Powder
• Molecular Formula: C24h25clfn5o3
• Assay: 99%
• Test Method: HPLC
• Molrcular Weight: 485.94
• Application: Cancer Treatment
• Shelf Life: 2 Years
• OEM: Customization Label and Packing Bottles
• Transport Package: Bottle and Carton
• Specification: 500mg/capsule
• Trademark: Customzied
• Origin: China
• HS Code: 29349990
• Production Capacity: 5000kg/Month

Product Description

Product Description

Afatinib is the first approved irreversible ErbB series blocker. The ErbB receptor family consists of 4 members: EGFR (ErbB1), HER2 (ErbB2), ErbB3 and ErbB4. ErbB family members communicate with other ErbB family members, and abnormal ErbB family signaling is a key driver of cancer cell growth and spread. Afatinib has two targets, EGFR and HER2, which can irreversibly block the mutation of epidermal growth receptor (EGFR) and the excessive performance of human epidermal receptor 2 (HER2) tyrosine kinase and stimulate abnormal internal information conduction in cells, permanently close the signaling channels on which cancer cells live, so that cancer cells cannot grow and reproduce, thereby treating cancer.

 

Product Specificaiton

Product Name:	Afatinib	Assay:	99%
Standard	Enterprise standard	Appearance:	White Crystalline Powder
CAS NO	439081-18-2	EINECS	1308068-626-2
Minimum  order  quantity	500g	Packing:	1kg/aluminum foil bag; 25kg/drum

Item	Requirements	Test Results
Description	Off-white powder	Off-white powder
Identification	HPLC ,NMR	Complies
Residue on Ignition	≤0.10%	0.05%
Loss on Drying	≤0.50%	0.15%
Heavy Metal	≤20ppm	<20ppm
Purity(HPLC)	≥99.0%	99.99%
Conclusion	It complies with EnterpriseStandard

 

Function & Application

Function:
Afatinib is a drug approved for the treatment non-small cell lung carcinoma(NSCLC), developed by Boehringer Ingelheim.It acts as a angiokinase inhibitor.Like lapatinib and neratinib, afatinib is a tyrosine kinase inhibitor (TKI) that also irreversibly inhibits human epidermal growth fector receptor 2 (Her2) and epidermal growth fector receptor (EGFR) kinases. Afatinib is not only active against EGFR mutations targeted by first generation TKIs likeerlotinib or gefitinib, but also against those not sensitive to these standard therapies. Because of its additional activity against Her2, it is being investigated for breast cancer as well as other EGFR and Her2 driven cancers.
Application:
1. Like lapatinib and neratinib, afatinib is a protein kinase inhibitor that also irreversibly inhibits human epidermal growth fector receptor 2 (Her2) and epidermal growth fector receptor (EGFR) kinases.
2. Afatinib is not only active against EGFR mutations targeted by first generation TKIs like erlotinib or gefitinib, but also against mutations such as T790M which are not sensitive to these standard therapies.Because of its additional activity against Her2, it is being investigated for breast cancer as well as other EGFR and Her2 driven cancers.
3. Afatinib is a drug for the first-line treatment of patients with distinct types of metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC).It acts as an irreversible covalent inhibitor of the receptor tyrosine kinases epidermal growth fector receptor (EGFR) and erbB-2 (HER2).

OEM Service

As a professional health product supplier, we can customize Afatinib powder with different packing, Afatinib capusel with different bottles according to your formula and requests.

                                                                   

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Packaging & Shipping

Goods weight	Packing	Shipping method	Lead-time
1-50kg	Below 5kg Use Foil bag;5-25kg use two layer PP bag,then into master carton or cardboard drum	International express	1~3 days after your payment
100-200kg	25kg/drum,use two layer PP bag,then into cardboard drum	Air shipping Sea Shipping	3~5 days after your payment
Over 500kg	25kg/drum,use two layer PP bag,then into cardboard drum	Sea shipping	5~10 days after your payment

 

Company Profile

FAQ

Q1: Can I get some free sample?

A: Yes, we offer free sample to client and you only need to pay the fright.

Q2: Could you accept customzied order? 
A: Yes, we accept customized service according your requests, you can communicate with sales manager to know more details.

Q3: When the product can be delivery? 
A: We normal delivery the product within 2-4 days, the more details will inform to you by our sales manager. 

Q4: Could i get certificate of analysis (COA) about product?
A: Of course, please contact us to get it. 
 

Q5: Is there any discount?

A:Yes, we can give you discount, but it depends on your quantity.