| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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Ibrutinib is a small molecule BTK inhibitor that can covalently bind to cysteine residues in the active center of BTK, thereby inhibiting its activity. The full name of BTK is Bruton'styrosinekinase, which transmits signals in the BCR signaling pathway and cytokine receptor signaling pathway, and mediates the migration, chemotaxis and adhesion of B cells. Preclinical studies have shown that ibrutinib can inhibit the proliferation and survival of malignant B cells.
Ibrutinib is a highly selective Bruton's tyrosine kinase (Btk) irreversible inhibitor.PCI-32765 (Ibrutinib) is a selective and irreversible pyrrolopyrimidine-based inhibitor of BTK with an IC50 of 0.5 nM. [1] PCI-32765 binds irreversibly to Cys-481 in BTK and thus is only active with other kinases with such a modifiable cysteine residue. In DOHH2 cells, in which the BCR pathway can be activated by anti-IgG, PCI-32765 inhibits autophosphorylation of BTK (IC50, 11 nM), BTK's physiological substrate, PLCg (IC50, 29 nm), and downstream ERK (IC50, 13 nm).
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| AHU-377 | AZD-9291 | UMP |
| LCZ696 | Baricitinib | Brigatinib |
| Ibrutinib | Apre milast | Veliparib |
We usual packaging the phenibut powder with Aluminum foil bag packaging (1kg/bag),Cardboard drum packaging (25kg/drum).
Packaging aniracetam capsule with bags, bottles,box,etc.
Q1: Could i start the order with small quantity ?
A: We accept sample order , the more details please contact us to know about.
Q2: Could you accept customzied order?
A: Yes, we accept customized service according your inquire, you can communicate with sales manager to know more details.
Q3: When the product can be delivery?
A: We normal delivery the product within 2-4 days, the more details will inform to you by our sales manager.
Q4: Could i get certificate of analysis (COA) about product?
A: Of course, please contact us to get it.
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