| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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What is Alectinib hydrochlorid ?
Alectinib hydrochloride, developed by Chugai Pharmaceutical/ Hoffman-La Roche under the trade name Alecensa, was approved in Japan in April 2014 for the treatment of anaplastic lymphoma kinase (ALK) fusion-gene positive, unresectable, advanced, or recurrent non-small cell lung cancer (NSCLC). The compound is a highly selective second-generation ALK inhibitor, and while alectinib currently remains a focus of further development in Europe and the U.S., the compound has been granted orphan drug designation in Japan after showing a 93.5% objective response rate in phase II clinical trials. In addition to providing rapid treatment response time in a majority of patients, trials showed a 76% 2-year progression-free survival rate. Since the initial approval of crizotinib-the first ALK inhibitor indicated for treatment of ALKrearranged NSCLC -patients treated with crizotinib have shown remarkable improvement as compared to treatment with other chemotherapeutic methods,21 although drug resistance has shown to be a major side effect of this therapy. Preliminary preclinical and clinical studies of alectinib have shown significant promise for overcoming drug resistance developed with other ALK inhibitors.
Alectinib hydrochloride is a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth. Also is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.
| Product name | Alectinib·HCl | |
| Appearance | White crystalline powder | |
| Purity | 99%min | |
| CAS No. | 1256580-46-7 | |
| EINECS No. | 616-640-4 | |
| MF. | C30H34N4O2 | |
1. Inhalation| Product Name | Alectinib·HCl | Sample | 30g/bag |
| CAS NO. | 1256580-46-7 | Test Method | HPLC |
| Appearance | White crystalline powder | Shelf Life | 2 Years |
| Grade | Pharmaceutical grade | Package | 25kg/drum |
| Item | SPECIFICATION | RESULAT |
| Appearance |
White Crystalline Powder | Complies |
| SO4 | 0.04% | 0.03% |
| Loss on Drying | <0.6% | 0.59% |
| Heavy Metals | ≤10ppm | Complies |
| Salt (by As) | ≤0.0002% | Complies |
| Chloride | ≤0.5% | 0.5% |
| Melting Point | 243.0-263.0ºC | Complies |
| Assay (KI) | 99% | 99.8% |
| Total plate count | ≤1000CFU/g | Complies |
| Yeast & mold | ≤1000CFU /g | Complies |
| E.coli | Negative | Complies |
| Salmonella | Negative | Complies |
Function:
Alectinib is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, alectinib binds to and inhibits ALK kinase, ALK fusion proteins as well as the gatekeeper mutation ALKL1196M known as one of the mechanisms of acquired resistance to small-molecule kinase inhibitors. The inhibition leads to disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells.
Application:
Alectinib (CH5424802) is an ATP-competitive inhibitor for ALK and L1196M with Ki values of 0.83 nM and 1.56 nM, respectively. CH5424802 prevents autophosphorylation of ALK, and also suppresses the phosphorylation of STAT3 and AKT, but not of ERK1/2. CH5424802 elicits an apoptotic marker-caspase-3/7-like activation-in NCI-H2228 spheroid cells. CH5424802 blocks the growth of two NPM-ALK expressing lymphoma lines, KARPAS-299 and SR with greater efficacy against KARPAS-299 at an IC50 of 3 nM.
As a professional health product supplier, we can customize Powder/Capsule with different packing, but also supply customized service (bottles/bags+labels).
If you have interested,welcome to consult.
>Click here to get more information
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1
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NMN
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21
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Fish Collagen
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2
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Coenzyme 10
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22
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Bovine Collagen
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3
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Tongkat Ali Extract 1% 5% 10%
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23
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Chicken Collagen
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4
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Ajuga Turkestanica Extract 10% Turkesterone
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24
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Astaxanthin 5% 10%
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5
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Epimedium Extract 10% 20% 98%
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25
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Lycopene 5% 10%
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6
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Ginseng Extract 80%
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26
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Matcha Powder
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7
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Osthole 50% 98%
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27
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Sodium Copper Chlorophyllin 99%
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8
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Fisetin 98%
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28
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Phosphatidylserine 20% 50% 70%
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9
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Beta Ecdysterone 90% 98%
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29
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Organic Wheatgrass Powder
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10
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Luteolin 98%
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30
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Organic Pea Protein Powder
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11
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Chaga Mushroom Extract 30%
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31
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Lutein 5% 10%
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12
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Reishi Mushroom Extract 30%
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32
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Beta Carotene 5% 10%
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13
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Lione's Mane Extract 30%
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33
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5-HTP 99%
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14
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Fenugreek Seed Extract 20% 40%
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34
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Instant Green Tea Powder
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15
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Quercetin 95%
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35
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Instant Black Tea Powder
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16
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Ashwagandha Root Extract
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36
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Dihydromyricetin 98%
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17
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Blueberry Extract
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37
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Ursolic Acid 50% 98%
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18
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Alpha Arbutin
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38
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Chondroitin Sulfate 90%
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19
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N-acetylneuraminic acid(Sialic Acid)
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39
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Kaempferol 98%
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20
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Green Coffee Bean Extract 50%
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40
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Saw Palmetto Extract 25% 45%
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We accept International Express--Fedex/DHL/UPS, air shipping and sea shipping
| Cargo weight | Packing | Shipping method | Lead-time |
| 1-50kg | Below 5kg Use Foil bag;5-25kg use two layer PP bag,then into master carton or cardboard drum | International express | 1~3 days after your payment |
| 100-200kg | 25kg/drum,use two layer PP bag,then into cardboard drum | Air shipping,Sea Shipping | 3~5 days after your payment |
| Over 500kg | 25kg/drum,use two layer PP bag,then into cardboard drum | Sea shipping | 5~10 days after your payment |
Xi'an Haoze Biotechnology Co., Ltd. Established in 2014, is a professional company engaged in the research, development, sales of health care material, cosmetics material and food additive ingredients. We are located in Xi'an City in the middle of China, which is back to Qinling Mountain, have a huge natural resources with convenient transportation.
We have excellent team who focus on product development & design, quality control & inspection, and company running. Dedicated to strict quality control and thoughtful customer service. There is a whole production line with extracting, column chromatography, reaction still, spray dry, freeze dry and vacuums dry equipment, it could produce 350kg finished product per hour, the annual production capacity is 2500-3000 tons. Also we have a full-scale of testing facility which are UV, HPLC, TLC and others. We own a GMP medical clean room which cover an area of 2000m2, and have research project with our local collage or institution every year. In addition, we have obtained ISO22000, HALAL and Kosher certificates to support different customer's request. We also welcome OEM and ODM orders. "Top Quality, Customer First" is our conviction, and we implement the principle of "high standards, safe & fast delivery, good service" to create a mutual benefit partnership with customers. We warmly welcome overseas customer to establish long-term cooperation.
Q1: Can I get some free sample?
A: Yes, we offer free sample to client and you only need to pay the fright.
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