| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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Orlistat is designed to treat obesity. Its primary function is preventing the absorption of fats from the human diet, thereby reducing caloric intake. Orlistat works by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine.
Orlistat blocks some of the fat that you eat, keeping it from being absorbed by your body.
Orlistat is used to aid in weight loss, or to help reduce the risk of regaining weight already lost. This medicine must be used together with a reduced-calorie diet.
Orlistat acts mainly on the gastrointestinal tract. It can inhibit the enzymes needed for digestion of fat in the gastrointestinal tract, including pancreatic and gastric esters, and reduce the absorption of fat by gastrointestinal esters to assist in weight loss.
Combined with a micro-low-energy diet for long-term treatment of obese and overweight people,including those who already have obesity-related risk factors. has the efficacy of long-term weight control (weight loss, maintenance and prevention of rebound).
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| Product Name: | Orlistat | Assay: | 99% |
| Appearance: | White crystalline powder | CAS NO: | 96829-58-2 |
| Formula: | C29H53NO5 | Molecular weight: | 495.73 |
| EINECS: | 639-755-1 | Application: | Pharmaceutical intermediate for weight loss |
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Function
Orlistat is a long-acting, powerful and specific gastrointestinal lipase inhibitor, which inactivates the above two enzymes by forming covalent bonds with lipase active serine sites in the stomach and small intestine. The inactivated enzymes cannot decompose the fats in food into free fatty acids and glycerol that can be absorbed by the human body, thus reducing fat intake and weight loss. In addition, it has been found that orlistat inhibits intestinal cholesterol absorption by inhibiting niemann-pickC1-like1 (NPC1L1).
Usage and Dosage
Orlistat combined with a slightly low caloric energy diet is indicated for the long-term treatment of obese and overweight patients including those who have developed obesity-related risk factors. Long-term weight control (weight loss, weight maintenance and weight loss prevention). It also reduces the incidence of obesity-related risk factors and other obesity-related diseases, including hypercholesterolemia and type 2 diabetes. For adults: The recommended dose is one 120mg capsule during or within one hour after a meal. If a meal is missed or the food does not contain fat, one dose of medication may be omitted. Long-term treatment effects, including weight control and improvement in risk factors, are sustainable. Patients should have a well-balanced diet with a low caloric energy, about 30% of which comes from fat, and a diet rich in fruits and vegetables. Fat, carbohydrate and protein intake should be divided into three meals a day. There is no evidence that more than 120mg three times a day enhances efficacy. Dose adjustment is not necessary for the elderly.
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